Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 9/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SI | P14410 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL133401 | 0.84 | MAOA (0.57) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL5612997 | 0.73 | MAOA (0.69) | MAOAKDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL30255441 | 0.73 | MAOA (0.69) | MAOAKDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL4452673 | 0.70 | MAOA (0.50) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL29833663 | 0.69 | MAOA (0.52) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL644478 | 0.69 | MAOA (0.52) | MAOAKDM4EALDH1A1GLACYP3A4 | |
| SCHEMBL4336089 | 0.67 | CYP3A4 (0.53) | MAOAKDM4EALDH1A1CYP3A4MAPT | |
| SCHEMBL3326973 | 0.67 | ALOX15 (0.50) | MAOAKDM4EALDH1A1CYP3A4HPGD | |
| SCHEMBL30435802 | 0.66 | MAOA (0.68) | MAOAKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL8485668 | 0.65 | MAOA (0.71) | MAOAKDM4EALDH1A1CYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137421-A1 | SMALL MOLECULE THERAPEUTICS, SYNTHESIS OF ANALOGUES AND DERIVATIVES AND METHODS OF USE | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2010-06-03 | — | — | US | disclosed |
| WO-2008057604-A9 | SMALL MOLECULE THERAPEUTICS, SYNTHESES OF ANALOGUES AND DERIVATIVES AND METHODS OF USE | UNIV CALIFORNIA (US) | 2008-10-02 | — | — | WO | disclosed |
| WO-2008057604-A2 | SMALL MOLECULE THERAPEUTICS, SYNTHESES OF ANALOGUES AND DERIVATIVES AND METHODS OF USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-05-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137421-A1 | SMALL MOLECULE THERAPEUTICS, SYNTHESIS OF ANALOGUES AND DERIVATIVES AND METHODS OF USE | BAD, CASP3, BID | MAOA 3590/4885KDM4E 2993/4885ALDH1A1 3574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.