Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 3/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | PIP4K2A | P48426 | 2/20 | 0.42 |
| ▸ | PIP4K2B | P78356 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 4/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3328120 | 0.91 | KDR (0.40) | ALDH1A1KMT2AMTORPIK3CAPIK3CG | |
| SCHEMBL8245334 | 0.83 | NISCH (0.35) | ALDH1A1POLBKDRFLT3NISCH | |
| SCHEMBL3326596 | 0.78 | NPC1 (0.47) | ALDH1A1KMT2APOLBKDRFLT3 | |
| SCHEMBL9115941 | 0.77 | AXL (0.53) | ALDH1A1KMT2AMTORPIK3CAPIK3CG | |
| SCHEMBL10805900 | 0.73 | ALDH1A1 (0.43) | ALDH1A1KMT2AMTORPIK3CAPIK3CG | |
| SCHEMBL10155599 | 0.73 | ALDH1A1 (0.78) | ALDH1A1KMT2APOLBPIP4K2APIP4K2B | |
| SCHEMBL3324137 | 0.73 | KIF11 (0.47) | ALDH1A1KMT2APOLBPIP4K2APIP4K2B | |
| SCHEMBL6768059 | 0.70 | KDR (0.43) | ALDH1A1KMT2AKDRNISCHKDM4E | |
| SCHEMBL3325615 | 0.70 | QDPR (0.41) | ALDH1A1KMT2AMTORPOLBKDM4E | |
| SCHEMBL11177479 | 0.69 | MDM2 (0.59) | ALDH1A1KMT2APIP4K2APIP4K2BROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148865-B1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GRENENTECH, INC. (US) | 2010-06-03 | — | — | US | disclosed |
| EP-2148865-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | Genentech, Inc. (US) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008137408-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | GENENTECH, INC. (US) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137394-A1 | PYRAZOLE INHIBITORS OF WNT SIGNALING | WNT1, WNT3A, CTNNB1 | ALDH1A1 1479/4885KMT2A 3775/4885MTOR 87/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.