SCHEMBL332855

SCHEMBL332855

C[Si](C)(O[SiH3])[Si](c1ccccc1)([Si](C)(C)O[SiH3])[Si](C)(C)O[SiH3]

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.37
ESR2 Q92731 1/20 0.37
NR1H2 P55055 2/20 0.34
NR1H3 Q13133 2/20 0.34
LTA4H P09960 2/20 0.32
TSHR P16473 1/20 0.32
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9296360 0.77 ESR1 (0.34) ESR1ESR2NR1H2NR1H3
SCHEMBL2233576 0.75 ESR1 (0.39) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL211428 0.75 ESR1 (0.39) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL7565872 0.73 ESR1 (0.38) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL11034567 0.71 ESR1 (0.37) ESR1ESR2NR1H2NR1H3
SCHEMBL2796775 0.71 ESR1 (0.44) ESR1ESR2NR1H2NR1H3TSHR
SCHEMBL8771307 0.71 ESR1 (0.44) ESR1ESR2NR1H2NR1H3LTA4H
Potassium Ion SCHEMBL11866555 0.70 ESR1 (0.35) ESR1ESR2
SCHEMBL11870662 0.70 ESR1 (0.35) ESR1ESR2
SCHEMBL2284805 0.70 ESR1 (0.35) ESR1ESR2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8097683-B2 Polyhedral oligomeric silsesquioxane and carborane containing network polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2012-01-17 US claimed
US-7723454-B2 Coating of organic fibers with siloxane-carborane polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-05-25 US claimed
US-20100120989-A1 Polyhedral Oligomeric Silsesquioxane and Carborane Containing Network Polymers THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-05-13 US claimed
US-7705100-B2 Coating of organic fibers with siloxane-carborane polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-04-27 US claimed
US-20090312568-A1 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE AND CARBORANE CONTAINING NETWORK THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-12-17 US claimed
US-20090238964-A1 COATING OF ORGANIC FIBERS WITH SILOXANE-CARBORANE POLYMERS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-09-24 US claimed
US-20090239070-A1 COATING OF ORGANIC FIBERS WITH SILOXANE-CARBORANE POLYMERS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-09-24 US claimed
US-20090018273-A1 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE AND CARBORANE CONTAINING NETWORK POLYMERS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-01-15 US claimed
US-8097683-B2 Polyhedral oligomeric silsesquioxane and carborane containing network polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2012-01-17 US disclosed
US-7723454-B2 Coating of organic fibers with siloxane-carborane polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-05-25 US disclosed
US-20100120989-A1 Polyhedral Oligomeric Silsesquioxane and Carborane Containing Network Polymers THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-05-13 US disclosed
US-7705100-B2 Coating of organic fibers with siloxane-carborane polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-04-27 US disclosed
US-7655738-B2 Polyhedral oligomeric silsesquioxane and carborane containing network polymers THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2010-02-02 US disclosed
US-20090312568-A1 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE AND CARBORANE CONTAINING NETWORK THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2009-12-17 US disclosed
US-7449535-B2 Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2008-11-11 US disclosed
US-20070161770-A1 SYNTHESIS OF ELASTOMERIC CARBORANE-SILOXANES BY HYDROSILATION REACTIONS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2007-07-12 US disclosed
US-20070161771-A1 SYNTHESIS OF ELASTOMERIC CARBORANE-SILOXANES BY HYDROSILATION REACTIONS THE GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2007-07-12 US disclosed
US-7238766-B2 Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 2007-07-03 US disclosed
WO-2006088485-A2 SYNTHESIS OF ELASTOMERIC CARBORANE-SILOXANES BY HYDROSILATION REACTIONS THE GOVERNMENT OF THE U.S.A., AS REPRESENTED BY THE SECRETARY OF THE NAVY, NAVAL RESEARCH LABORATORY (US) 2006-08-24 WO disclosed
US-20050171316-A1 Synthesis of elastomeric carborane-siloxanes by hydrosilation reactions THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY 2005-08-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090312568-A1 POLYHEDRAL OLIGOMERIC SILSESQUIOXANE AND CARBORANE CONTAINING NETWORK PARN, CBX4, TRIM58 ESR1 774/4885ESR2 2041/4885NR1H2 2755/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.