Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 7/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 4/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | GRM8 | O00222 | 2/20 | 1.00 |
| ▸ | GRM6 | O15303 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 1/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.50 |
| ▸ | GRM3 | Q14832 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.50 |
| ▸ | PLCB1 | Q9NQ66 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659587 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL3954836 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL8476727 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL659588 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL12648585 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL13319984 | 1.00 | GRM4 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL1064244 | 0.79 | CYP1A2 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL1063416 | 0.79 | CYP1A2 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL1263461 | 0.79 | CYP1A2 (1.00) | GRM4CYP1A2CYP2C19ALDH1A1TDP1 | |
| SCHEMBL15060220 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210161910-A1 | Combining BACE1 Inhibitors With mGluR Agonists For Alzheimer's Disease Therapy | UNIVERSITY OF CONNECTICUT | 2021-06-03 | — | — | US | disclosed |
| EP-2046358-B1 | INDUCTION OF ANALGESIA IN NEUROPATHIC PAIN | UNIV EDINBURGH (GB) | 2015-07-22 | — | — | EP | disclosed |
| US-9034798-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CAPROTEC BIOANALYTICS GMBH (DE) | 2015-05-19 | — | — | US | disclosed |
| US-8569481-B2 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PHARMACEUTICALS, INC. (US) | 2013-10-29 | — | — | US | disclosed |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | KOESTER HUBERT | 2011-05-19 | — | — | US | disclosed |
| US-20100298168-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-11-25 | — | — | US | disclosed |
| US-20100248264-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | HK PHARMACEUTICALS, INC. | 2010-09-30 | — | — | US | disclosed |
| US-20100137344-A1 | INDUCTION OF ANALGESIA IN NEUROPATHIC PAIN | UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2010-06-03 | — | — | US | disclosed |
| US-20080027127-A1 | Trans Pyrrolidinyl Derivates and Their Pharmaceutical Use | FAUST PHARMACEUTICALS (FR) | 2008-01-31 | — | — | US | disclosed |
| US-7129073-B2 | Regulation of neuronal function through metabotropic glutamate receptor signaling pathways | THE ROCKEFELLER UNIVERSITY (US) | 2006-10-31 | — | — | US | disclosed |
| US-20060223158-A1 | REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210161910-A1 | Combining BACE1 Inhibitors With mGluR Agonists For Alzheimer's Disease Therapy | BACE1, PSEN1, PSEN2 | GRM4 17/4885CYP1A2 4795/4885CYP2C19 4723/4885 |
| US-20110118136-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | PTMS, QPCTL, SRMS | GRM4 4466/4885CYP1A2 4732/4885CYP2C19 4485/4885 |
| US-20100298168-A1 | Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions | CHLSN, PTMS, SRMS | GRM4 4676/4885CYP1A2 4648/4885CYP2C19 4619/4885 |
| US-20080027127-A1 | Trans Pyrrolidinyl Derivates and Their Pharmaceutical Use | SUCNR1, GLRA1, CNR1 | GRM4 48/4885CYP1A2 1922/4885CYP2C19 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.