Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHOC | P08134 | 12/20 | 0.39 |
| ▸ | RHOA | P61586 | 12/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 2/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3325513 | 0.88 | GSK3B (0.39) | ALDH1A1MEN1KMT2AMAPTCYP2D6 | |
| SCHEMBL3325069 | 0.85 | KCNMA1 (0.47) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3574142 | 0.84 | PSEN1 (0.44) | RHOCRHOAMEN1KMT2APSEN1 | |
| SCHEMBL2890988 | 0.81 | HDAC2 (0.45) | ALDH1A1ACLY | |
| SCHEMBL3277364 | 0.81 | TRPM2 (0.40) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3277357 | 0.81 | TRPM2 (0.40) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3576165 | 0.80 | GRIK1 (0.48) | MAPT | |
| SCHEMBL1463053 | 0.80 | ACLY (0.50) | ALDH1A1ACLYMAPTTACR1 | |
| SCHEMBL3329456 | 0.79 | CA12 (0.44) | ALDH1A1MEN1KMT2AACLYKDM4E | |
| SCHEMBL3581371 | 0.78 | NTRK1 (0.53) | MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | claimed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | claimed |
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | KCNAB1, KCNJ2, KCNN3 | RHOC 4068/4885RHOA 4424/4885ALDH1A1 3067/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.