Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | IGF2BP2 | Q9Y6M1 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | XBP1 | P17861 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 3/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | USP36 | Q9P275 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3329633 | 0.88 | RHOC (0.39) | MEN1ALDH1A1KMT2AMAPTCYP2D6 | |
| SCHEMBL3577239 | 0.85 | PSEN1 (0.42) | SERPINE1TRPV1MAPTPKMXBP1 | |
| SCHEMBL3325069 | 0.82 | KCNMA1 (0.47) | MEN1ALDH1A1KMT2AMAPTPKM | |
| SCHEMBL3328613 | 0.80 | CCNA2 (0.44) | GSK3BMEN1KMT2APPARAWNT3A | |
| SCHEMBL2890988 | 0.79 | HDAC2 (0.45) | ALDH1A1 | |
| SCHEMBL1463053 | 0.78 | ACLY (0.50) | ALDH1A1MAPT | |
| SCHEMBL3579750 | 0.76 | DGAT1 (0.42) | GSK3BDHODHABL1PPARASCN10A | |
| SCHEMBL3584115 | 0.76 | PSEN1 (0.45) | GSK3BMAPTPSEN1PSEN2APH1B | |
| SCHEMBL3582672 | 0.76 | DGAT1 (0.42) | GSK3BGCGR | |
| SCHEMBL3579491 | 0.75 | PSEN1 (0.47) | TRPV1MAPTABL1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | claimed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | claimed |
| EP-2155700-B1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH AS (DK) | 2010-10-06 | — | — | EP | disclosed |
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2010-06-03 | — | — | US | disclosed |
| EP-2155700-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NeuroSearch A/S (DK) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008135448-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | NEUROSEARCH A/S (DK) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137387-A1 | BETA-KETO-AMIDE DERIVATIVES USEFUL AS ION CHANNEL MODULATORS | KCNAB1, KCNJ2, KCNN3 | GSK3B 1665/4885SERPINE1 4167/4885TRPV1 91/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.