Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | HTT | P42858 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 6/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | XBP1 | P17861 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.55 |
| ▸ | PPIA | P62937 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19688778 | 0.86 | MGLL (0.76) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL964881 | 0.84 | MEN1 (0.78) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL20029049 | 0.84 | MGLL (0.59) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL333191 | 0.83 | SMN1; SMN2 (0.65) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL5027273 | 0.83 | NLRP3 (0.53) | ALDH1A1HTTMAPTGAAMGLL | |
| SCHEMBL5142569 | 0.82 | MAPT (0.77) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL29550745 | 0.81 | KMT2A (0.84) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL1603669 | 0.81 | SMN1; SMN2 (0.74) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL8347078 | 0.81 | SMN1; SMN2 (0.66) | ALDH1A1HTTMEN1KMT2AMAPT | |
| SCHEMBL5142590 | 0.81 | MAPT (0.77) | ALDH1A1HTTMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1620391-B1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2014-01-15 | — | — | EP | disclosed |
| US-8097629-B2 | Dihydropyridinone derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-17 | — | — | US | disclosed |
| US-8097629-B2 | Dihydropyridinone derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-17 | — | — | US | disclosed |
| US-8097629-B2 | Dihydropyridinone derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-01-17 | — | — | US | disclosed |
| EP-1720857-B1 | DIHYDROPYRIDINONE DERIVATIVES | BAYER SCHERING PHARMA AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| US-7696205-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2010-04-13 | — | — | US | disclosed |
| US-20080108678-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY | 2008-05-08 | — | — | US | disclosed |
| US-20080045541-A1 | Dihydropyridinone Derivatives | BAYER-HEALTHCARE AG (DE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045541-A1 | Dihydropyridinone Derivatives | BAYER-HEALTHCARE AG (DE) | 2008-02-21 | — | — | US | disclosed |
| US-20080045541-A1 | Dihydropyridinone Derivatives | BAYER-HEALTHCARE AG (DE) | 2008-02-21 | — | — | US | disclosed |
| US-7291615-B2 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-11-06 | — | — | US | disclosed |
| EP-1620391-A4 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2007-10-31 | — | — | EP | disclosed |
| EP-1720857-A1 | DIHYDROPYRIDINONE DERIVATIVES | Bayer HealthCare AG (DE) | 2006-11-15 | — | — | EP | disclosed |
| EP-1620391-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Bristol-Myers Squibb Company (US) | 2006-02-01 | — | — | EP | disclosed |
| WO-2005080372-A1 | DIHYDROPYRIDINONE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-09-01 | — | — | WO | disclosed |
| WO-2005080372-A1 | DIHYDROPYRIDINONE DERIVATIVES | BAYER HEALTHCARE AG (DE) | 2005-09-01 | — | — | WO | disclosed |
| US-20040235836-A1 | Cyclic derivatives as modulators of chemokine receptor activity | BRISTOL-MYERS SQUIBB COMPANY | 2004-11-25 | — | — | US | disclosed |
| WO-2004098516-A2 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235836-A1 | Cyclic derivatives as modulators of chemokine receptor activity | CCL11, CCR1, CCL2 | ALDH1A1 1095/4885HTT 4462/4885MEN1 2716/4885 |
| US-20080108678-A1 | CYCLIC DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | CCL11, CCL2, CCR1 | ALDH1A1 1345/4885HTT 4443/4885MEN1 3068/4885 |
| US-20080045541-A1 | Dihydropyridinone Derivatives | TNNI3, DHPS, TNNT2 | ALDH1A1 721/4885HTT 4647/4885MEN1 4426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.