SCHEMBL3333108

SCHEMBL3333108

COC(=O)c1nc(-c2c(F)cc(Cl)c(OC)c2F)cc(NC(C)=O)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.38
PYGL P06737 2/20 0.35
CYP1A2 P05177 1/20 0.33
NQO2 P16083 1/20 0.33
KDM4E B2RXH2 1/20 0.32
NPC1 O15118 1/20 0.32
HPGD P15428 1/20 0.32
NFKB1 P19838 1/20 0.32
RAB9A P51151 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
ABL1 P00519 2/20 0.32
ADORA3 P0DMS8 2/20 0.32
AGER Q15109 1/20 0.32
ACLY P53396 1/20 0.32
TAS1R3 Q7RTX0 1/20 0.32
TAS1R1 Q7RTX1 1/20 0.32
TAS1R2 Q8TE23 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3840578 0.92 ACLY (0.36) ALDH1A1PYGLCYP1A2KDM4ENPC1
SCHEMBL16095650 0.92 ALDH1A1 (0.38) ALDH1A1PYGLCYP1A2NQO2KDM4E
SCHEMBL17797192 0.88 ALDH1A1 (0.38) ALDH1A1PYGLCYP1A2NQO2KDM4E
SCHEMBL16044403 0.86 ALDH1A1 (0.38) ALDH1A1PYGLCYP1A2NQO2KDM4E
SCHEMBL2470016 0.85 PYGL (0.35) ALDH1A1PYGLCYP1A2KDM4ENPC1
SCHEMBL29557036 0.85 ALDH1A1 (0.36) ALDH1A1CYP1A2NQO2KDM4ESMN1; SMN2
SCHEMBL16127200 0.85 ALDH1A1 (0.36) ALDH1A1CYP1A2NQO2KDM4ENPC1
SCHEMBL16036011 0.85 ALDH1A1 (0.36) ALDH1A1CYP1A2NQO2KDM4ESMN1; SMN2
SCHEMBL17797232 0.84 PYGL (0.34) ALDH1A1PYGLCYP1A2KDM4ENPC1
SCHEMBL1918400 0.84 ALDH1A1 (0.43) ALDH1A1ABL1ADORA3TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8962523-B2 Herbicide/safener combination BAYER CROPSCIENCE AG (DE) 2015-02-24 US disclosed
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2015-02-19 US disclosed
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION BAYER CROPSCIENCE AG (DE) 2010-06-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137137-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 ALDH1A1 209/4885PYGL 2325/4885CYP1A2 16/4885
US-20150051074-A1 HERBICIDE/SAFENER COMBINATION DDT, CYP2W1, GAP43 ALDH1A1 209/4885PYGL 2325/4885CYP1A2 16/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.