Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 3/20 | 0.46 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | STAT6 | P42226 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008150 | 0.81 | P2RX7 (0.46) | P2RX7EHMT2HCRTR1HCRTR2MEN1 | |
| SCHEMBL1008151 | 0.81 | P2RX7 (0.46) | P2RX7EHMT2HCRTR1HCRTR2MEN1 | |
| SCHEMBL1189963 | 0.81 | P2RX7 (0.46) | P2RX7EHMT2HCRTR1HCRTR2MEN1 | |
| SCHEMBL6852820 | 0.80 | P2RX7 (0.46) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 | |
| SCHEMBL3333492 | 0.80 | P2RX7 (0.56) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 | |
| SCHEMBL6133226 | 0.79 | P2RX7 (0.45) | P2RX7EHMT2HCRTR1HCRTR2ALDH1A1 | |
| SCHEMBL1190522 | 0.79 | P2RX7 (0.58) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 | |
| SCHEMBL12018713 | 0.79 | P2RX7 (0.46) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 | |
| SCHEMBL10215486 | 0.79 | P2RX7 (0.47) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 | |
| SCHEMBL12495007 | 0.79 | P2RX7 (0.47) | P2RX7EHMT2HCRTR1HCRTR2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144727-A1 | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators | BESWICK PAUL JOHN | 2010-06-10 | — | — | US | disclosed |
| EP-2139875-A2 | OXAZOLIDINE AND MORPHOLINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008119685-A2 | OXAZOLIDINE AND MORPHOLINE CARBOXAMIDE DERIVATIVES AS P2X7 MODULATORS | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144727-A1 | Oxazolidine and Morpholine Carboxamide Derivatives as P2X7 Modulators | P2RX5, P2RX3, P2RX7 | P2RX7 3/4885EHMT2 4388/4885HCRTR1 129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.