Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13301912 | 0.91 | AAK1 (0.45) | AAK1NR4A2CAMK2DMTNR1AMTNR1B | |
| SCHEMBL15944117 | 0.88 | NR4A2 (0.43) | NR4A2MTNR1AMTNR1BCTSLCTSS | |
| SCHEMBL17826908 | 0.88 | MTNR1A (0.54) | AAK1NR4A2CAMK2DMTNR1AMTNR1B | |
| SCHEMBL15944824 | 0.86 | MTNR1A (0.39) | AAK1CAMK2DMTNR1AMTNR1BCTSL | |
| SCHEMBL3333209 | 0.86 | NR4A2 (0.44) | AAK1NR4A2CAMK2DMTNR1AMTNR1B | |
| SCHEMBL3334978 | 0.86 | NR4A2 (0.44) | AAK1NR4A2CAMK2DMTNR1AMTNR1B | |
| SCHEMBL3331422 | 0.86 | MTNR1A (0.57) | NR4A2MTNR1AMTNR1B | |
| SCHEMBL17826934 | 0.85 | AAK1 (0.43) | AAK1NR4A2CAMK2DMTNR1AMTNR1B | |
| SCHEMBL17826910 | 0.85 | KMT2A (0.42) | MTNR1AMTNR1BCTSLCTSSCTSK | |
| SCHEMBL13301913 | 0.84 | MAPT (0.49) | CAMK2DCTSLCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9676715-B2 | Bis-indolic derivatives, a process for preparing the same and their uses as a drug | UNIVERSITE JOSEPH FOURIER (FR) | 2017-06-13 | — | — | US | disclosed |
| EP-2121601-B1 | NOVEL INDOLE DERIVATIVES, METHODS FOR PREPARING SAME, AND USE THEREOF PARTICULARLY AS ANTIBACTERIAL AGENTS | Université Joseph Fourier (FR) | 2016-06-15 | — | — | EP | disclosed |
| EP-2121601-B1 | NOVEL INDOLE DERIVATIVES, METHODS FOR PREPARING SAME, AND USE THEREOF PARTICULARLY AS ANTIBACTERIAL AGENTS | Université Joseph Fourier (FR) | 2016-06-15 | — | — | EP | disclosed |
| US-9321722-B2 | Bis-indolic derivatives, their uses in particular as antibacterials | UNIVERSITE JOSEPH FOURIER (FR) | 2016-04-26 | — | — | US | disclosed |
| US-20140309272-A1 | BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | UNIVERSITE JOSEPH FOURIER (FR) | 2014-10-16 | — | — | US | disclosed |
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | UNIVERSITE JOSEPH FOURIER (FR) | 2014-08-14 | — | — | US | disclosed |
| EP-2548865-B1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | UNIV JOSEPH FOURIER (FR) | 2014-03-05 | — | — | EP | disclosed |
| EP-2548864-B1 | NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | UNIV JOSEPH FOURIER (FR) | 2014-02-19 | — | — | EP | disclosed |
| EP-2548864-A1 | NOVEL BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | Université Joseph Fourier (FR) | 2013-01-23 | — | — | EP | disclosed |
| EP-2548865-A1 | Novel bis-indolic derivatives, their uses in particular as antibacterials | Université Joseph Fourier (FR) | 2013-01-23 | — | — | EP | disclosed |
| US-8343964-B2 | Indolic derivatives, their preparation processes and their uses in particular as antibacterials | UNIVERSITE JOSEPH FOURIER (FR) | 2013-01-01 | — | — | US | disclosed |
| US-8343964-B2 | Indolic derivatives, their preparation processes and their uses in particular as antibacterials | UNIVERSITE JOSEPH FOURIER (FR) | 2013-01-01 | — | — | US | disclosed |
| US-20100144726-A1 | NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS | UNIVERSITE JOSEPH FOURIER (FR) | 2010-06-10 | — | — | US | disclosed |
| US-20100144726-A1 | NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS | UNIVERSITE JOSEPH FOURIER (FR) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228359-A1 | BIS-INDOLIC DERIVATIVES, THEIR USES IN PARTICULAR AS ANTIBACTERIALS | IDO1, IDO2, AANAT | AAK1 2460/4885NR4A2 3867/4885CAMK2D 721/4885 |
| US-20140309272-A1 | BIS-INDOLIC DERIVATIVES, A PROCESS FOR PREPARING THE SAME AND THEIR USES AS A DRUG | IDO1, ITPA, IDO2 | AAK1 1981/4885NR4A2 4000/4885CAMK2D 1030/4885 |
| US-20100144726-A1 | NOVEL INDOLIC DERIVATIVES, THEIR PREPARATION PROCESSES AND THEIR USES IN PARTICULAR AS ANTIBACTERIALS | GPBAR1, TPH1, GPER1 | AAK1 3461/4885NR4A2 831/4885CAMK2D 3216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.