Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | CTSV | O60911 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MIF | P14174 | 1/20 | 0.33 |
| ▸ | WNT1 | P04628 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11514694 | 0.75 | CTSV (0.41) | FGFR3KDRCTSVCTSLCTSS | |
| SCHEMBL30442984 | 0.74 | ALDH1A1 (0.53) | LMNAIDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL31301193 | 0.74 | KDM4E (0.53) | TAAR1IDO1HSD17B1ALDH1A1MEN1 | |
| SCHEMBL5573502 | 0.74 | HSD17B1 (0.61) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL31264268 | 0.74 | NOTUM (0.46) | IDO1KMT2APIM1SMN1; SMN2NPC1 | |
| SCHEMBL25488567 | 0.74 | ALDH1A1 (0.53) | LMNAIDO1ALDH1A1MEN1KMT2A | |
| SCHEMBL572719 | 0.72 | PDPK1 (0.45) | CTSVCTSLCTSSCTSKTAAR1 | |
| SCHEMBL30610817 | 0.70 | ALDH1A1 (0.51) | LMNACYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1174898 | 0.70 | TRIM24 (0.41) | FGFR3KDRCTSVCTSLCTSS | |
| SCHEMBL27757412 | 0.68 | GOT1 (0.44) | CTSVCTSLCTSSLMNANOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868604-B1 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | HARVARD COLLEGE (US) | 2014-08-13 | — | — | EP | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| EP-1868604-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-12-26 | — | — | EP | disclosed |
| WO-2006078942-A2 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2006-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144805-A1 | Regulation of protein synthesis | EIF4EBP1, RNMT, NCBP1 | FGFR3 4326/4885KDR 4629/4885CTSV 3095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.