Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRE11 | P49959 | 3/20 | 0.67 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.64 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | PRKACA | P17612 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3331466 | 0.87 | PKM (0.65) | MRE11ELOVL1GPR142NPC1RAB9A | |
| SCHEMBL13357576 | 0.84 | ROCK1 (0.67) | ELOVL1GPR142ROCK1PRKACAMAPT | |
| SCHEMBL12678090 | 0.82 | ELOVL1 (0.60) | ELOVL1GPR142NPC1RAB9AROCK1 | |
| SCHEMBL9179947 | 0.82 | ELOVL1 (0.60) | ELOVL1GPR142NPC1RAB9AROCK1 | |
| SCHEMBL29430089 | 0.81 | MRE11 (1.00) | MRE11 | |
| SCHEMBL21484703 | 0.81 | MRE11 (1.00) | MRE11 | |
| SCHEMBL2752589 | 0.80 | LMNA (0.68) | ELOVL1NPC1RAB9AROCK1MAPT | |
| SCHEMBL21225987 | 0.79 | HDAC6 (0.66) | MRE11ELOVL1NPC1RAB9AROCK1 | |
| SCHEMBL21225986 | 0.79 | HDAC6 (0.66) | MRE11ELOVL1NPC1RAB9AROCK1 | |
| SCHEMBL4949871 | 0.79 | HDAC6 (0.66) | MRE11ELOVL1NPC1RAB9AROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1868604-B1 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | HARVARD COLLEGE (US) | 2014-08-13 | — | — | EP | disclosed |
| EP-1868604-B1 | REGULATION OF PROTEIN SYNTHESIS BY INHIBITION OF EIF4E-EIF4G INTERACTION | HARVARD COLLEGE (US) | 2014-08-13 | — | — | EP | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-8257931-B2 | Regulation of protein synthesis | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
| US-20100144805-A1 | Regulation of protein synthesis | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144805-A1 | Regulation of protein synthesis | EIF4EBP1, RNMT, NCBP1 | MRE11 3878/4885ELOVL1 2824/4885GPR142 4239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.