Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | PTPRF | P10586 | 1/20 | 0.55 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL564987 | 0.91 | HTT (0.64) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL22669878 | 0.89 | HTT (0.57) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL455536 | 0.89 | MEN1 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL3422016 | 0.89 | MEN1 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL5154356 | 0.89 | MEN1 (0.50) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL2065031 | 0.89 | CYP1A2 (0.69) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL31396238 | 0.88 | HTT (0.56) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| SCHEMBL11936095 | 0.88 | FFAR1 (0.63) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL2985269 | 0.86 | MAOA (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 | |
| Hydrochloric Acid SCHEMBL4949253 | 0.86 | MAOA (0.48) | CYP1A2CYP3A4CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268713-B1 | PROCESS FOR MAKING POLYAMINOPOLYPHENYL METHANES USING A MIXED SOLID ACID CATALYST SYSTEM | DOW GLOBAL TECHNOLOGIES LLC (US) | 2018-02-21 | — | — | EP | claimed |
| EP-1616890-B1 | Method for producing of polyamines of the diphenylmethane series with low degree of protonation | COVESTRO DEUTSCHLAND AG (DE) | 2016-11-30 | — | — | EP | claimed |
| EP-2019092-B1 | PROCESS FOR PRODUCING POLYAMINE | MITSUI CHEMICALS INC (JP) | 2013-07-03 | — | — | EP | claimed |
| EP-2019092-A1 | PROCESS FOR PRODUCING POLYAMINE | Mitsui Chemicals Polyurethanes, Inc. (JP) | 2009-01-28 | — | — | EP | claimed |
| US-7253321-B2 | Process for the preparation of polyamines of the diphenylmethane series at a low degree of protonation | BAYER MATERIALSCIENCE AG (DE) | 2007-08-07 | — | — | US | claimed |
| US-20060287555-A1 | Process for the preparation of polyamines of the diphenylmethane series at a low degree of protonation | COVESTRO DEUTSCHLAND AG (DE) | 2006-12-21 | — | — | US | claimed |
| EP-1616890-A1 | Method for producing of polyamines of the diphenylmethane series with low degree of protonation | Bayer MaterialScience AG (DE) | 2006-01-18 | — | — | EP | claimed |
| US-5241119-A | Condensation of aniline with aldehyde; isomerization of chemical intermediate; using zeolite catalys | ENIRICERCHE S.P.A. (IT) | 1993-08-31 | — | — | US | claimed |
| EP-0264744-B1 | PROCESS FOR THE PREPARATION OF 4,4'-DIAMINODIPHENYLMETHANE AND ITS DERIVATIVES | ENIRICERCHE S.p.A. (IT) | 1992-12-23 | — | — | EP | claimed |
| EP-0264744-A2 | Process for the preparation of 4,4'-diaminodiphenylmethane and its derivatives | ENIRICERCHE S.p.A. (IT) | 1988-04-27 | — | — | EP | claimed |
| EP-4345088-B1 | A PROCESS FOR PREPARING DI- AND POLYAMINES OF THE DIPHENYL METHANE SERIES | COVESTRO DEUTSCHLAND AG (DE) | 2025-10-22 | — | — | EP | disclosed |
| CN-119684159-A | Method for reducing content of hydrolytic chlorine in isocyanate | 万华化学(福建)异氰酸酯有限公司 | 2025-03-25 | — | — | CN | disclosed |
| EP-4345088-A1 | A PROCESS FOR PREPARING DI- AND POLYAMINES OF THE DIPHENYL METHANE SERIES | Covestro Deutschland AG (DE) | 2024-04-03 | — | — | EP | disclosed |
| CN-117430767-A | Process for the preparation of diamines and polyamines of the diphenylmethane series | 科思创德国股份有限公司 | 2024-01-23 | — | — | CN | disclosed |
| WO-2023186874-A1 | DISPERSE AZO DYES BASED ON 2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID | HUNTSMAN ADVANCED MATERIALS (SWITZERLAND) GMBH (CH) | 2023-10-05 | — | — | WO | disclosed |
| US-4147724-A | Process for the preparation of polyamines | BAYER AKTIENGESELLSCHAFT (DE) | 1979-04-03 | — | — | US | disclosed |
| US-4146727-A | ACID CATALYSTS | ATLANTIC RICHFIELD COMPANY (US) | 1979-03-27 | — | — | US | disclosed |
| US-4110070-A | QUATERNIZING INDOLENINE METHINE COMPOUND ON FIBERS TO FORM CATIONIC DYE | HODOGAYA CHEMICAL CO., LTD. (JP) | 1978-08-29 | — | — | US | disclosed |
| US-4093658-A | CONDENSING AN AROMATIC AMINE WITH FORMALDEHYDE | BAYER AKTIENGESELLSCHAFT (DT) | 1978-06-06 | — | — | US | disclosed |
| US-4087459-A | Process for the preparation of polyamines | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287555-A1 | Process for the preparation of polyamines of the diphenylmethane series at a low degree of protonation | SRM, PNMT, DNMT1 | CYP1A2 1969/4885CYP3A4 1894/4885CYP2C9 3396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.