Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 3/20 | 0.59 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.59 |
| ▸ | PTPRC | P08575 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | F2R | P25116 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | PTGES | O14684 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5332281 | 0.87 | KCNK3 (0.75) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL2638776 | 0.86 | PTGS1 (0.70) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL21022150 | 0.86 | LMNA (0.66) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL678924 | 0.84 | PTGS1 (0.72) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL96040 | 0.84 | KCNK3 (0.59) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL8363754 | 0.84 | KCNK3 (0.64) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL20601679 | 0.83 | KCNK3 (0.66) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL30791183 | 0.82 | LMNA (0.69) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL21652266 | 0.82 | PTGES (0.62) | KCNK3KCNK9PTGS1PTPRCLMNA | |
| SCHEMBL12334663 | 0.81 | RORC (0.71) | KCNK3KCNK9PTGS1PTPRCLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137305-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-03 | — | — | US | disclosed |
| CN-101675041-A | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMA | 2010-03-17 | — | — | CN | disclosed |
| EP-2142537-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | Vertex Pharmaceuticals Incorporated (US) | 2010-01-13 | — | — | EP | disclosed |
| WO-2008115973-A2 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137305-A1 | AMINOPYRIMIDINES USEFUL AS KINASE INHIBITORS | AURKC, AURKA, AURKB | KCNK3 1603/4885KCNK9 1888/4885PTGS1 2890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.