SCHEMBL333630

SCHEMBL333630

CC(=O)SC[Si](C)(C)OC(C)C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.31
CYP2C19 P33261 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL333725 0.83 TSHR (0.31) TSHRCYP2C19
SCHEMBL333517 0.81 TSHR (0.32) TSHRCYP2C19
SCHEMBL19640281 0.80 CYP2C19 (0.36) CYP2C19
SCHEMBL333659 0.72 ALDH1A1 (0.32) CYP2C19
SCHEMBL27523582 0.72 CYP2C19 (0.36) CYP2C19
SCHEMBL334696 0.67 CYP2C19 (0.33) CYP2C19
SCHEMBL13089240 0.67 TSHR (0.36) TSHR
SCHEMBL19640282 0.66 TSHR (0.31) TSHR
SCHEMBL333892 0.64 CYP2C19 (0.34) CYP2C19
SCHEMBL15837221 0.64

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 166 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113795499-A Process for producing alkoxysilyl group-containing thiocarboxylic ester 迈图高新材料公司 2021-12-14 CN claimed
US-10919920-B2 Method for the manufacture of alkoxysilyl-containing thiocarboxylic acid esters MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2021-02-16 US claimed
US-20200347084-A1 METHOD FOR THE MANUFACTURE OF ALKOXYSILYL-CONTAINING THIOCARBOXYLIC ACID ESTERS MOMENTIVE PERFORMANCE MATERIALS INC. 2020-11-05 US claimed
EP-2978768-B1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE MOMENTIVE PERFORMANCE MAT INC (US) 2017-11-29 EP claimed
EP-1341843-B2 MINERAL-FILLED ELASTOMER COMPOSITIONS MOMENTIVE PERFORMANCE MAT INC (US) 2016-03-23 EP claimed
EP-2978768-A1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE Momentive Performance Materials Inc. (US) 2016-02-03 EP claimed
EP-1560836-B1 PROCESS FOR MANUFACTURE OF BLOCKED MERCAPTOSILANE COUPLING AGENTS MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-30 EP claimed
US-9206203-B2 Catalytic process for the preparation of thiocarboxylate silane MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2015-12-08 US claimed
WO-2014160786-A1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-10-02 WO claimed
US-20140296553-A1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-10-02 US claimed
US-6635700-B2 Mixture of a latent mercaptosilane coupling agent and an additional mercaptan activator used to cure sulfur vulcanizable rubber CROMPTON CORPORATION 2003-10-21 US claimed
EP-1341843-A2 MINERAL-FILLED ELASTOMER COMPOSITIONS Crompton Corporation (US) 2003-09-10 EP claimed
EP-0958298-B1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS CROMPTON CORP (US) 2003-05-07 EP claimed
US-6528673-B2 Reacting a mercaptosilane and a monoacid anhydride corresponding to a thioester group present in the desired product, or reacting alkali salt of a mercaptosilane with an acid anhydride or acid halide or transesterification CROMPTON CORPORATION 2003-03-04 US claimed
US-20020115767-A1 Mineral-filled elastomer compositions MOMENTIVE PERFORMANCE MATERIALS INC. 2002-08-22 US claimed
US-6414061-B1 CURABLE MIXTURE CROMPTON CORPORATION 2002-07-02 US claimed
WO-2002048256-A2 MINERAL-FILLED ELASTOMER COMPOSITIONS CROMPTON CORPORATION (US) 2002-06-20 WO claimed
US-20020055646-A1 Reacting a mercaptosilane and a monoacid anhydride corresponding to a thioester group present in the desired product, or reacting alkali salt of a mercaptosilane with an acid anhydride or acid halide or transesterification WITCO CORPORATION 2002-05-09 US claimed
EP-0958298-A1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS WITCO CORPORATION (US) 1999-11-24 EP claimed
WO-1999009036-A1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS OSI SPECIALTIES, INC. (US) 1999-02-25 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140296553-A1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE TST, STS, CTH TSHR 2903/4885CYP2C19 629/4885
US-10919920-B2 Method for the manufacture of alkoxysilyl-containing thiocarboxylic acid esters TST, MPST, APEH TSHR 1254/4885CYP2C19 2094/4885
US-20200347084-A1 METHOD FOR THE MANUFACTURE OF ALKOXYSILYL-CONTAINING THIOCARBOXYLIC ACID ESTERS TST, MPST, APEH TSHR 1254/4885CYP2C19 2094/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.