Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 4/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3333558 | 0.88 | CTSV (0.41) | HDAC4HDAC6CTSVCTSLCTSB | |
| SCHEMBL3337876 | 0.86 | ROCK2 (0.48) | HDAC4HDAC6TRPM8CTSVCTSL | |
| SCHEMBL13300017 | 0.82 | ATM (0.42) | HDAC4HDAC6TRPM8CTSVCTSL | |
| SCHEMBL3330752 | 0.81 | HDAC4 (0.46) | HDAC4HDAC6TRPM8HDAC1ROCK2 | |
| SCHEMBL4553029 | 0.80 | TRPM8 (0.41) | TRPM8CTSVCTSLCTSBCTSS | |
| SCHEMBL4432711 | 0.79 | CTSL (0.39) | HDAC4HDAC6TRPM8CTSVCTSL | |
| SCHEMBL1530008 | 0.79 | HDAC8 (0.38) | HDAC4HDAC6CTSVCTSLCTSB | |
| SCHEMBL1529754 | 0.78 | HDAC8 (0.38) | HDAC4HDAC6CTSVCTSLCTSB | |
| SCHEMBL1529393 | 0.78 | MCL1 (0.38) | CTSVCTSLCTSBCTSSROCK2 | |
| SCHEMBL1529712 | 0.78 | HDAC8 (0.43) | HDAC4HDAC6CTSVCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8338434-B2 | Inhibitors of Akt activity | GLAXOSMITHKLINE LLC (US) | 2012-12-25 | — | — | US | disclosed |
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137338-A1 | INHIBITORS OF Akt ACTIVITY | PI4KB, AKT3, AKT2 | HDAC4 674/4885HDAC6 339/4885TRPM8 4679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.