Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4554202 | 0.88 | CTSV (0.42) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL3337876 | 0.82 | ROCK2 (0.48) | TRPM8CTSLCTSVCTSBCTSS | |
| SCHEMBL4430001 | 0.81 | TRPM8 (0.41) | TRPM8PPARG | |
| SCHEMBL3336362 | 0.80 | HDAC4 (0.43) | TRPM8CTSLCTSVCTSBCTSS | |
| SCHEMBL4371338 | 0.79 | HDAC8 (0.40) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL13300017 | 0.79 | ATM (0.42) | TRPM8CTSLCTSVCTSBCTSS | |
| SCHEMBL4542245 | 0.78 | AKT1 (0.39) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4542689 | 0.78 | HDAC8 (0.39) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4384617 | 0.77 | HDAC8 (0.43) | CTSLCTSVCTSBCTSSHDAC8 | |
| SCHEMBL4540876 | 0.77 | AKT1 (0.43) | CTSLCTSVCTSBCTSSHDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2134175-A1 | INHIBITORS OF AKT ACTIVITY | Smithkline Beecham Corporation (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2008121786-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-09 | — | — | WO | disclosed |