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Sugi Predict / Compounds / 2-Amino-4-Nitrophenol

2-Amino-4-Nitrophenol

2-Amino-4-Nitrophenol

SCHEMBL3337658

Nc1cc([N+](=O)[O-])ccc1O.O=S(=O)(O)O

nearest known ligand 0.86

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

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

The experimentally established mechanism targets of 2-Amino-4-Nitrophenol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GAA P10253 3/20 0.86
▸ THRB P10828 1/20 0.86
▸ ALDH1A1 P00352 5/20 0.55
▸ GPR35 Q9HC97 3/20 0.55
▸ TSHR P16473 3/20 0.55
▸ TP53 P04637 1/20 0.55
▸ HPGD P15428 1/20 0.55
▸ MAPK1 P28482 1/20 0.55
▸ SMN1; SMN2 Q16637 1/20 0.55
▸ HSD17B10 Q99714 1/20 0.55
▸ NT5E P21589 1/20 0.54
▸ CYP3A4 P08684 3/20 0.53
▸ TDP1 Q9NUW8 6/20 0.53
▸ ALOX15 P16050 2/20 0.53
▸ MAPT P10636 2/20 0.52
▸ CA12 O43570 2/20 0.52
▸ CA1 P00915 2/20 0.52
▸ CA2 P00918 2/20 0.52
▸ CA9 Q16790 2/20 0.52
▸ ERN1 O75460 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Amino-4-Nitrophenol SCHEMBL31297314 0.93 GAA (1.00) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL22943 0.93 GAA (1.00) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL6894960 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL31193638 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL19950506 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL6894954 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL19950746 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL11137165 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL19950745 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR
2-Amino-4-Nitrophenol SCHEMBL19950749 0.91 GAA (0.96) GAATHRBALDH1A1GPR35TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583876-B2 Branched organosilicon compound, method of preparing same, and related compositions DOW SILICONES CORPORATION (US) 2026-03-24 — — US disclosed
EP-3493878-B1 COSMETIC COMPOSITION COMPRISING CURED SILICONE MATERIALS DOW SILICONES CORP (US) 2025-10-08 — — EP disclosed
US-12398270-B2 Acrylate-functional branched organosilicon compound, method of preparing same, and copolymer formed therewith DOW SILICONES CORPORATION (US) 2025-08-26 — — US disclosed
US-12371535-B2 Branched organosilicon compound, method of preparing same, and copolymer formed therewith DOW SILICONES CORPORATION (US) 2025-07-29 — — US disclosed
US-12338259-B2 Branched organosilicon compound, method of preparing same, and copolymer formed therewith DOW SILICONES CORPORATION (US) 2025-06-24 — — US disclosed
US-12269833-B2 Branched organosilicon compound, method of preparing same, and compositions comprising same DOW SILICONES CORPORATION (US) 2025-04-08 — — US disclosed
US-12215198-B2 Branched organosilicon compound, method of preparing same, and compositions comprising same DOW SILICONES CORPORATION (US) 2025-02-04 — — US disclosed
US-20240245600-A1 ORRIS ROOT EXTRACTS, COMPOSITIONS, AND METHODS FOR SKIN APPLICATIONS ACCESS BUSINESS GROUP INT LLC (US) 2024-07-25 — — US disclosed
US-11986547-B2 Cosmetic composition comprising silicone materials DOW SILICONES CORPORATION (US) 2024-05-21 — — US disclosed
CN-117794504-A Iris root extract, compositions and methods for dermatological use 捷通国际有限公司 2024-03-29 — — CN disclosed
US-20140127140-A1 Cosmetic Composition Comprising Hydrophilic Organosilanes DOW CORNING CORPORATION (US) 2014-05-08 — — US disclosed
WO-2014070639-A2 COSMETIC COMPOSITION COMPRISING HYDROPHILIC ORGANOSILANES DOW CORNING CORPORATION (US) 2014-05-08 — — WO disclosed
WO-2014023958-A1 ELASTOMERIC POWDERS DOW CORNING CORPORATION (US) 2014-02-13 — — WO disclosed
CN-103547316-A Personal care and health care compositions DOW CORNING 2014-01-29 — — CN disclosed
US-20130336909-A1 PERSONAL CARE AND HEALTH CARE COMPOSITIONS DOW CORNING CORPORATION (US) 2013-12-19 — — US disclosed
EP-2663279-A2 PERSONAL CARE COMPOSITIONS Dow Corning Corporation (US) 2013-11-20 — — EP disclosed
WO-2012095399-A2 PERSONAL CARE AND HEALTH CARE COMPOSITIONS DOW CORNING CORPORATION (US) 2012-07-19 — — WO disclosed
US-20100143274-A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS CIBA CORPORATION (US) 2010-06-10 — — US disclosed
EP-2120846-A2 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS BASF SE (DE) 2009-11-25 — — EP disclosed
WO-2008107347-A2 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS BASF SE (CH) 2008-09-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12215198-B2 Branched organosilicon compound, method of preparing same, and compositions comprising same ORC3, OXSR1, OR10J3 GAA 4594/4885THRB 2190/4885ALDH1A1 4242/4885
US-20100143274-A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS MAOA, MAOB, ACMSD GAA 999/4885THRB 3050/4885ALDH1A1 464/4885
US-12583876-B2 Branched organosilicon compound, method of preparing same, and related compositions OXSR1, BRS3, NPSR1 GAA 4501/4885THRB 696/4885ALDH1A1 3531/4885
US-12269833-B2 Branched organosilicon compound, method of preparing same, and compositions comprising same NR3C2, NR2E3, OXER1 GAA 4768/4885THRB 831/4885ALDH1A1 4302/4885
US-12338259-B2 Branched organosilicon compound, method of preparing same, and copolymer formed therewith OXSR1, BRS3, ORC3 GAA 3655/4885THRB 1710/4885ALDH1A1 3760/4885
US-12371535-B2 Branched organosilicon compound, method of preparing same, and copolymer formed therewith OXSR1, BRS3, OXER1 GAA 4550/4885THRB 603/4885ALDH1A1 2965/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.