Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CCR2 | P41597 | 1/20 | 0.37 |
| ▸ | WNT3A | P56704 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1784883 | 0.96 | AKR1C3 (0.48) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3346142 | 0.90 | OPRM1 (0.45) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3341377 | 0.90 | OPRM1 (0.45) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3346083 | 0.90 | OPRM1 (0.44) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3340297 | 0.89 | KCNH2 (0.49) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| Trifluoroacetic Acid SCHEMBL3340025 | 0.88 | OPRM1 (0.47) | OPRM1OPRD1OPRK1KCNH2SHMT1 | |
| Trifluoroacetic Acid SCHEMBL3338278 | 0.87 | OPRM1 (0.50) | OPRM1OPRD1OPRK1KDM1AMAOA | |
| Trifluoroacetic Acid SCHEMBL3339667 | 0.85 | DPP4 (0.42) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 | |
| SCHEMBL1347866 | 0.84 | OPRM1 (0.49) | OPRM1OPRD1OPRK1KCNH2KDM1A | |
| Trifluoroacetic Acid SCHEMBL3338541 | 0.84 | FAAH (0.42) | AKR1C3AKR1C2OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | GLAXOSMITHKLINE LLC | 2014-10-30 | — | — | US | disclosed |
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | IGNAR DIANE MICHELE | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113512-A1 | METHOD OF TREATMENT USING NOVEL ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | OPRL1, OPRD1, OPRK1 | AKR1C3 2572/4885AKR1C2 1973/4885OPRM1 4/4885 |
| US-20140323487-A1 | Novel Compounds As Antagonists Or Inverse Agonists At Opioid Receptors | OPRL1, OPRM1, OPRK1 | AKR1C3 2428/4885AKR1C2 2353/4885OPRM1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.