Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | PDE8B | O95263 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3340212 | 1.00 | ALDH1A1 (0.33) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL3342926 | 1.00 | ALDH1A1 (0.33) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL3342929 | 0.72 | ALDH1A1 (0.33) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL3340214 | 0.72 | ALDH1A1 (0.33) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL3341705 | 0.72 | ALDH1A1 (0.33) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL6363797 | 0.70 | TDP1 (0.32) | ALDH1A1TDP1MEN1CYP1A2CYP3A4 | |
| SCHEMBL30515668 | 0.68 | ALDH1A1 (0.37) | ALDH1A1MCL1HPGDTDP1MEN1 | |
| SCHEMBL6239955 | 0.65 | ALDH1A1 (0.34) | ALDH1A1HPGDTDP1MEN1CYP1A2 | |
| SCHEMBL17437783 | 0.60 | PKM (0.37) | ALDH1A1HPGDMEN1PKMKMT2A | |
| SCHEMBL16112324 | 0.58 | TSHR (0.32) | ALDH1A1HPGDMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252798-B2 | Purine compounds | ELI LILLY AND COMPANY (US) | 2012-08-28 | — | — | US | disclosed |
| US-20100160288-A1 | Purine Compounds | ELI LILLY AND COMPANY | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160288-A1 | Purine Compounds | P2RX1, P2RX7, P2RX5 | ALDH1A1 1108/4885MCL1 2615/4885HPGD 251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.