Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 20/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3343069 | 0.82 | CYP11B2 (0.39) | P2RX7 | |
| SCHEMBL16335719 | 0.75 | P2RX7 (0.49) | P2RX7 | |
| SCHEMBL3347437 | 0.74 | CYP2A13 (0.55) | — | |
| SCHEMBL16335337 | 0.71 | NPC1 (0.39) | P2RX7 | |
| SCHEMBL12931886 | 0.69 | ALDH1A1 (0.44) | P2RX7 | |
| SCHEMBL20695806 | 0.68 | KDM4E (0.44) | P2RX7 | |
| SCHEMBL22771044 | 0.68 | GRIN1 (0.39) | — | |
| SCHEMBL259624 | 0.67 | GRM2 (0.53) | — | |
| SCHEMBL14002387 | 0.67 | SMN1; SMN2 (0.55) | — | |
| SCHEMBL9826977 | 0.67 | ACHE (0.54) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | P2RX7 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.