Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 2/20 | 0.40 |
| ▸ | POLG | P54098 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | POLA1 | P09884 | 1/20 | 0.39 |
| ▸ | HPRT1 | P00492 | 8/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL676634 | 0.85 | KDM4E (0.43) | PNPKDM4EMEN1RGS12LMNA | |
| SCHEMBL3345014 | 0.77 | PNP (0.31) | PNPPOLG | |
| Pyrophosphoric Acid SCHEMBL25186018 | 0.75 | KDM4E (0.30) | KDM4EMAPT | |
| SCHEMBL3721701 | 0.71 | KDM4E (0.46) | PNPPOLGKDM4EMEN1RGS12 | |
| Pyrophosphoric Acid SCHEMBL2935409 | 0.69 | KDM4E (0.49) | PNPPOLGKDM4EMEN1RGS12 | |
| Triphosphate SCHEMBL28078341 | 0.69 | POLG (0.52) | PNPPOLGHSD17B10POLBPOLA1 | |
| SCHEMBL3343322 | 0.68 | POLG (0.31) | POLG | |
| SCHEMBL1533829 | 0.68 | KDM4E (0.45) | PNPPOLGKDM4EMEN1RGS12 | |
| Triphosphate SCHEMBL6461190 | 0.65 | MAPT (0.68) | PNPPOLGMAPTPOLBPOLA1 | |
| Triphosphate SCHEMBL12813216 | 0.65 | PNP (0.70) | PNPPOLGKDM4EMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117417872-A | Cell or strain for treating phenylketonuria, medicament and application | 苏州普瑞森生物科技有限公司 | 2024-01-19 | — | — | CN | disclosed |
| EP-2201107-B1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | UNIV WESTERN HEALTH SCIENCES (US) | 2019-01-16 | — | — | EP | disclosed |
| US-20130218546-A1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2013-08-22 | — | — | US | disclosed |
| US-8328934-B2 | Crystal of GTP Cyclohydrolase Type IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2012-12-11 | — | — | US | disclosed |
| US-20100291608-A1 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-11-18 | — | — | US | disclosed |
| EP-2201107-A2 | NOVEL GTP CYCLOHYDROLASE TYPE IB | Western University Of Health Sciences (US) | 2010-06-30 | — | — | EP | disclosed |
| WO-2010039115-A9 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010039115-A2 | NOVEL GTP CYCLOHYDROLASE TYPE IB | WESTERN UNIVERSITY OF HEALTH SCIENCES (US) | 2010-04-08 | — | — | WO | disclosed |