Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 12/20 | 0.43 |
| ▸ | AKR1A1 | P14550 | 5/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346227 | 0.92 | AKR1B1 (0.39) | AKR1B1AKR1A1PTGDR2KDM4EMAPT | |
| SCHEMBL3345145 | 0.81 | PTGDR2 (0.41) | PTGDR2KDM4E | |
| SCHEMBL3346049 | 0.81 | PLA2G2A (0.41) | PTGDR2KDM4EMAPT | |
| SCHEMBL3344022 | 0.76 | PLA2G1B (0.49) | PTGDR2KDM4EMAPT | |
| SCHEMBL3345090 | 0.74 | ALDH1A1 (0.41) | AKR1B1AKR1A1PTGDR2KDM4EMAPT | |
| SCHEMBL3345066 | 0.74 | TDP1 (0.43) | PTGDR2KDM4EMAPTPPARD | |
| SCHEMBL3345023 | 0.73 | PLA2G1B (0.44) | PTGDR2KDM4EMAPT | |
| SCHEMBL3345055 | 0.73 | ALDH1A1 (0.42) | PTGDR2KDM4EMAPT | |
| SCHEMBL3346252 | 0.73 | PLA2G2A (0.44) | PTGDR2KDM4E | |
| SCHEMBL3345142 | 0.72 | ALDH1A1 (0.45) | KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |