Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | PTGIR | P43119 | 1/20 | 0.41 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.34 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.34 |
| ▸ | PLA2G2E | Q9NZK7 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.33 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.33 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345055 | 0.92 | ALDH1A1 (0.42) | PTGDR2PTGIRPTGDRKDM4EPLA2G2A | |
| SCHEMBL3346049 | 0.82 | PLA2G2A (0.41) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3344698 | 0.81 | AKR1B1 (0.43) | PTGDR2KDM4E | |
| SCHEMBL3344022 | 0.77 | PLA2G1B (0.49) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3345066 | 0.75 | TDP1 (0.43) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3345023 | 0.75 | PLA2G1B (0.44) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3346252 | 0.74 | PLA2G2A (0.44) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3346104 | 0.73 | PLA2G10 (0.41) | PTGDR2KDM4EPLA2G10PLA2G1BPLA2G2A | |
| SCHEMBL3345075 | 0.73 | TDP1 (0.49) | PTGDR2PTGDRKDM4EPLA2G10PLA2G1B | |
| SCHEMBL3345142 | 0.73 | ALDH1A1 (0.45) | KDM4EPLA2G2AALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |