Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344656 | 0.88 | TP53 (0.41) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3349053 | 0.83 | ALDH1A1 (0.45) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3344676 | 0.83 | TDP1 (0.44) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL5327554 | 0.79 | PTGDR2 (0.81) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3348106 | 0.78 | PTGDR2 (0.49) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3780495 | 0.77 | PTGDR2 (0.48) | PTGDR2KMT2AKDM4ESMN1; SMN2PTGS2 | |
| SCHEMBL3344745 | 0.77 | PTGDR2 (0.48) | PTGDR2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3348700 | 0.77 | ALDH1A1 (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3345122 | 0.76 | ALDH1A1 (0.43) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL3404915 | 0.75 | PTGS1 (0.38) | ALDH1A1MAPTMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |