Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.39 |
| ▸ | PLA2G2E | Q9NZK7 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344715 | 0.87 | PTGDR2 (0.44) | TDP1TSHRALDH1A1MEN1KMT2A | |
| SCHEMBL3348700 | 0.87 | ALDH1A1 (0.41) | TSHRPKMALDH1A1MEN1KMT2A | |
| SCHEMBL3344758 | 0.83 | PTGDR2 (0.51) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3345079 | 0.82 | ALDH1A1 (0.42) | PKMALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL3345539 | 0.82 | ALDH1A1 (0.46) | TSHRPKMALDH1A1MEN1KMT2A | |
| SCHEMBL3348773 | 0.80 | ALDH1A1 (0.47) | TSHRPKMALDH1A1KDM4EHPGD | |
| SCHEMBL3349053 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL3347965 | 0.80 | ALDH1A1 (0.48) | TDP1TSHRALDH1A1MAPTKDM4E | |
| SCHEMBL3404915 | 0.80 | PTGS1 (0.38) | ALDH1A1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL5329822 | 0.79 | PKM (0.61) | TSHRPKMALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |