Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | RGS12 | O14924 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345114 | 0.91 | PTGDR2 (0.53) | PTGDR2PLA2G2AP2RX3ALDH1A1TSHR | |
| SCHEMBL3345040 | 0.90 | PTGDR2 (0.39) | PTGDR2PLA2G2AP2RX3ALDH1A1TSHR | |
| SCHEMBL3348106 | 0.88 | PTGDR2 (0.49) | PTGDR2PLA2G2AP2RX3ALDH1A1TSHR | |
| SCHEMBL3348857 | 0.85 | PLA2G10 (0.46) | PLA2G2AP2RX3ALDH1A1TSHRKDM4E | |
| SCHEMBL3345534 | 0.81 | KDM4E (0.44) | PTGDR2PLA2G2AP2RX3ALDH1A1TSHR | |
| SCHEMBL3409928 | 0.80 | ALDH1A1 (0.40) | PLA2G2AP2RX3ALDH1A1TSHRKDM4E | |
| SCHEMBL3346140 | 0.77 | PTGDR2 (0.38) | PTGDR2P2RX3ALDH1A1TSHRKDM4E | |
| SCHEMBL3344758 | 0.77 | PTGDR2 (0.51) | PTGDR2ALDH1A1KDM4EHPGDMEN1 | |
| SCHEMBL3344376 | 0.76 | PLA2G2A (0.55) | PTGDR2PLA2G2AP2RX3TSHRLMNA | |
| SCHEMBL5327554 | 0.76 | PTGDR2 (0.81) | PTGDR2ALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | claimed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |