Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.53 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3344745 | 0.91 | PTGDR2 (0.48) | PTGDR2PLA2G2APTGESALOX5LMNA | |
| SCHEMBL3345534 | 0.91 | KDM4E (0.44) | PTGDR2PLA2G2ALMNAHTTP2RX3 | |
| SCHEMBL3348106 | 0.85 | PTGDR2 (0.49) | PTGDR2PLA2G2APTGESALOX5LMNA | |
| SCHEMBL3344376 | 0.85 | PLA2G2A (0.55) | PTGDR2PLA2G2AALOX5LMNAHTT | |
| SCHEMBL3345040 | 0.81 | PTGDR2 (0.39) | PTGDR2PLA2G2ALMNAP2RX3ALDH1A1 | |
| SCHEMBL3345462 | 0.81 | PLA2G2A (0.45) | PTGDR2PLA2G2APTGESLMNAHTT | |
| SCHEMBL3348857 | 0.76 | PLA2G10 (0.46) | PLA2G2AP2RX3ALDH1A1MAPTPKM | |
| SCHEMBL3346140 | 0.75 | PTGDR2 (0.38) | PTGDR2LMNAP2RX3ALDH1A1MEN1 | |
| SCHEMBL3344758 | 0.75 | PTGDR2 (0.51) | PTGDR2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5327554 | 0.74 | PTGDR2 (0.81) | PTGDR2LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010040989-A1 | QUINOLIN-2-ONE COMPOUNDS | ARGENTA ORAL THERAPEUTICS LIMITED (GB) | 2010-04-15 | — | — | WO | disclosed |