Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.36 |
| ▸ | HTR7 | P34969 | 6/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 5/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346311 | 0.88 | KDM4E (0.36) | HTR1AHTR7DRD2GAAMAPT | |
| SCHEMBL3347067 | 0.86 | MEN1 (0.35) | HTR1AGAAMAPTRAD52GFER | |
| SCHEMBL3346768 | 0.81 | ALDH1A1 (0.44) | GAAMAPTGFERMAPK1ALDH1A1 | |
| SCHEMBL521121 | 0.80 | DRD2 (0.46) | HTR1AHTR7HTR6DRD2MAPT | |
| SCHEMBL521120 | 0.80 | DRD2 (0.46) | HTR1AHTR7HTR6DRD2MAPT | |
| SCHEMBL12714783 | 0.79 | ALDH1A1 (0.54) | HTR1ADRD2GAAMAPTRAD52 | |
| SCHEMBL11297059 | 0.76 | LMNA (0.50) | HTR1AHTR7HTR6DRD2MAPT | |
| SCHEMBL3309920 | 0.76 | ALDH1A1 (0.55) | MAPTGFERMAPK1ALDH1A1L3MBTL1 | |
| SCHEMBL2204046 | 0.76 | IGF1R (0.42) | HTR1ADRD2GAAMAPTALDH1A1 | |
| SCHEMBL3346986 | 0.75 | GAA (0.39) | GAAMAPTRAD52GFERMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |