Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.39 |
| ▸ | RAD52 | P43351 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3345841 | 0.87 | HPGD (0.46) | GAAMAPTHPGDALDH1A1MEN1 | |
| SCHEMBL3347067 | 0.85 | MEN1 (0.35) | GAARAD52MAPTGFERHPGD | |
| SCHEMBL15358684 | 0.82 | MAPT (0.44) | GAARAD52MAPTGFERALDH1A1 | |
| SCHEMBL3346311 | 0.78 | KDM4E (0.36) | GAARAD52MAPTGFERHPGD | |
| SCHEMBL15653140 | 0.78 | MAPT (0.67) | GAARAD52MAPTGFERALDH1A1 | |
| SCHEMBL3345933 | 0.75 | HTR1A (0.36) | GAARAD52MAPTGFERALDH1A1 | |
| SCHEMBL16096011 | 0.75 | ALDH1A1 (0.38) | GAARAD52MAPTGFERPRMT1 | |
| SCHEMBL3315976 | 0.72 | ALDH1A1 (0.60) | MAPTGFERALDH1A1MEN1KMT2A | |
| SCHEMBL6507555 | 0.72 | MAPT (0.56) | GAARAD52MAPTGFERALDH1A1 | |
| SCHEMBL3345950 | 0.72 | ALDH1A1 (0.44) | GAAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |