Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346195 | 0.90 | MAPT (0.41) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3346768 | 0.87 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAKDM4ERECQL | |
| SCHEMBL3345950 | 0.83 | ALDH1A1 (0.44) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3347067 | 0.80 | MEN1 (0.35) | MAPTALDH1A1LMNAKDM4EGAA | |
| SCHEMBL2207788 | 0.79 | MAPT (0.40) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3309164 | 0.78 | MAPT (0.49) | MAPTALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL3345168 | 0.76 | ALDH1A1 (0.49) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL3345838 | 0.76 | ALDH1A1 (0.48) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL20591963 | 0.75 | ALDH1A1 (0.57) | MAPTALDH1A1LMNAKDM4ESMN1; SMN2 | |
| SCHEMBL15994800 | 0.75 | SIRT6 (0.69) | MAPTALDH1A1LMNAKDM4ESIRT6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010049731-A1 | PYRAZOLO- AND IMIDAZOPYRIDINYLPYRIMIDINEAMINES AS IGF-1R TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2010-05-06 | — | — | WO | disclosed |