Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 7/20 | 0.35 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021183 | 0.84 | TTR (0.38) | TTRBACE1TPMTALOX15TSHR | |
| SCHEMBL2814523 | 0.82 | TTR (0.39) | TTRTPMTALOX15TSHRHIF1A | |
| SCHEMBL3469217 | 0.82 | CA12 (0.34) | BACE1KMT2A | |
| SCHEMBL898570 | 0.78 | TTR (0.44) | TTRTPMTALOX15TSHRHIF1A | |
| SCHEMBL7875993 | 0.78 | HCAR3 (0.43) | BACE1 | |
| SCHEMBL3478647 | 0.78 | HCAR3 (0.43) | BACE1 | |
| Hydrochloric Acid SCHEMBL899209 | 0.77 | TTR (0.42) | TTRTPMTALOX15TSHRHIF1A | |
| SCHEMBL7946697 | 0.77 | BACE1 (0.34) | BACE1 | |
| SCHEMBL3350177 | 0.75 | KDM4C (0.44) | EGLN1ALDH1A1KDM4E | |
| SCHEMBL7880963 | 0.75 | BACE1 (0.42) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010107384-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-09-23 | — | — | WO | disclosed |
| WO-2010042030-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-15 | — | — | WO | disclosed |
| WO-2010042030-A1 | ASPARTYL PROTEASE INHIBITORS | MEDIVIR AB (SE) | 2010-04-15 | — | — | WO | disclosed |