Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.49 |
| ▸ | RELA | Q04206 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10665204 | 0.74 | GAA (0.51) | KMT2AALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL11768769 | 0.74 | TSHR (0.48) | KMT2AALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL31140232 | 0.74 | HTT (0.69) | KMT2AALDH1A1MAPTSMN1; SMN2RAB9A | |
| SCHEMBL11728162 | 0.73 | POLB (0.55) | ALDH1A1GAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL345503 | 0.72 | CRBN (0.38) | KMT2AALDH1A1MAPTSMN1; SMN2PKM | |
| SCHEMBL31126366 | 0.71 | POLB (0.53) | ALDH1A1GAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL11647947 | 0.70 | CYP2C9 (0.57) | ALDH1A1GAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL27552925 | 0.70 | HTT (0.59) | KMT2AALDH1A1GAAMAPTSMN1; SMN2 | |
| SCHEMBL14413877 | 0.70 | ALDH1A1 (1.00) | ALDH1A1GAAMAPTSMN1; SMN2TP53 | |
| SCHEMBL27338294 | 0.69 | SMN1; SMN2 (0.55) | KMT2AALDH1A1GAAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144885-B1 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI SA (FR) | 2016-06-29 | — | — | EP | disclosed |
| US-8735437-B2 | Imidazolidine carboxamide derivatives as lipase and phospholipase inhibitors | SANOFI (FR) | 2014-05-27 | — | — | US | disclosed |
| US-20100105719-A1 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (FR) | 2010-04-29 | — | — | US | disclosed |
| EP-2144885-A1 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | Sanofi-Aventis (FR) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008122352-A1 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | SANOFI-AVENTIS (FR) | 2008-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105719-A1 | IMIDAZOLIDINE CARBOXAMIDE DERIVATIVES AS LIPASE AND PHOSPHOLIPASE INHIBITORS | PNLIP, PLD1, PLD2 | KMT2A 1644/4885ALDH1A1 577/4885GAA 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.