Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 6/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | ACKR3 | P25106 | 5/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3350848 | 0.88 | ROCK2 (0.41) | TRPM5SSTR4ROCK2KCNH2MAPK1 | |
| SCHEMBL3346446 | 0.86 | ROCK2 (0.42) | TRPM5ROCK2KCNH2MAPK1 | |
| SCHEMBL3347822 | 0.86 | KCNH2 (0.45) | ROCK2KCNH2 | |
| SCHEMBL3353119 | 0.86 | KCNH2 (0.47) | SSTR4KCNH2ACKR3 | |
| SCHEMBL3349710 | 0.83 | KCNQ3 (0.46) | KCNH2 | |
| SCHEMBL3346658 | 0.83 | KCNH2 (0.40) | SSTR4ROCK2KCNH2MAPK1 | |
| SCHEMBL13365057 | 0.83 | KCNH2 (0.38) | TRPM5SSTR4ROCK2KCNH2MAPK1 | |
| SCHEMBL3350804 | 0.82 | MAPK1 (0.41) | ROCK2KCNH2MAPK1 | |
| SCHEMBL3380842 | 0.80 | KCNH2 (0.40) | ROCK2KCNH2MAPK1 | |
| SCHEMBL13365050 | 0.80 | SSTR4 (0.39) | SSTR4ROCK2KCNH2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |