Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KCNB1 | Q14721 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | MC4R | P32245 | 6/20 | 0.34 |
| ▸ | APLNR | P35414 | 2/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346544 | 0.88 | TRPM5 (0.38) | ROCK2MAPK1SSTR4KCNH2TRPM5 | |
| SCHEMBL13365045 | 0.87 | MC4R (0.43) | ROCK2ROCK1CHRNA7MC4RKCNH2 | |
| SCHEMBL3346552 | 0.87 | KCNH2 (0.45) | ROCK2ROCK1CHRNA7KCNA5KCNB1 | |
| SCHEMBL3346446 | 0.84 | ROCK2 (0.42) | ROCK2MAPK1KCNH2TRPM5 | |
| SCHEMBL13365053 | 0.84 | CHRNA7 (0.43) | ROCK2ROCK1CHRNA7KCNA5KCNB1 | |
| SCHEMBL3346689 | 0.82 | POLB (0.50) | ROCK2ROCK1 | |
| SCHEMBL3349710 | 0.81 | KCNQ3 (0.46) | CHRNA7KCNH2 | |
| SCHEMBL3350804 | 0.80 | MAPK1 (0.41) | ROCK2ROCK1MAPK1KCNH2 | |
| SCHEMBL3350852 | 0.80 | MC4R (0.37) | ROCK2MC4RTRPM5 | |
| SCHEMBL13365057 | 0.79 | KCNH2 (0.38) | ROCK2CHRNA7MAPK1SSTR4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | disclosed |