Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 2/20 | 0.38 |
| ▸ | CA2 | P00918 | 2/20 | 0.38 |
| ▸ | CA7 | P43166 | 2/20 | 0.38 |
| ▸ | CA9 | Q16790 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 10/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346158 | 0.87 | CYP2A6 (0.44) | CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL3348895 | 0.85 | CHRM2 (0.40) | CHRM2CHRM1DYRK1ACYP2C9 | |
| SCHEMBL3347005 | 0.85 | ALOX5 (0.40) | DYRK1AALOX5 | |
| SCHEMBL3346741 | 0.85 | ADORA2B (0.42) | CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3348468 | 0.84 | GRM5 (0.45) | DYRK1ASCN5ACYP1A2ALOX5 | |
| SCHEMBL3346523 | 0.84 | CYP2A6 (0.35) | CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3346865 | 0.82 | CHRM2 (0.35) | CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3346516 | 0.82 | ALOX5 (0.37) | CHRM2CHRM1DYRK1ASCN5AALOX5 | |
| SCHEMBL3345871 | 0.82 | CHRM2 (0.35) | CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3348444 | 0.80 | CHRM2 (0.35) | CHRM2CHRM1DYRK1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |