Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 8/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346741 | 0.86 | ADORA2B (0.42) | GRM5EGLN1CHRNB2CHRNA4ADORA2B | |
| SCHEMBL3348895 | 0.86 | CHRM2 (0.40) | GRM5EGLN1CHRNB2CHRNA4DYRK1A | |
| SCHEMBL3347130 | 0.85 | CA12 (0.38) | ALOX5DYRK1A | |
| SCHEMBL3346728 | 0.85 | GRM5 (0.38) | ALOX5GRM5FFAR1HTTEGLN1 | |
| SCHEMBL3346158 | 0.81 | CYP2A6 (0.44) | GRM5CHRNB2CHRNA4 | |
| SCHEMBL3347309 | 0.80 | GRM5 (0.53) | GRM5TGFBR1 | |
| SCHEMBL3346516 | 0.79 | ALOX5 (0.37) | ALOX5GRM5FFAR1TGFBR1DYRK1A | |
| SCHEMBL3346840 | 0.78 | GRM5 (0.36) | GRM5FFAR1HTTSMN1; SMN2TGFBR1 | |
| SCHEMBL3346523 | 0.78 | CYP2A6 (0.35) | GRM5DYRK1A | |
| SCHEMBL3346980 | 0.76 | GRM5 (0.49) | GRM5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |