Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 3/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3342192 | 0.82 | ALPL (0.49) | MEN1KMT2AALPLCA9 | |
| SCHEMBL3346937 | 0.81 | MKNK1 (0.51) | USP30DRD4MEN1KMT2AMKNK1 | |
| SCHEMBL3346609 | 0.77 | LMNA (0.54) | MEN1KMT2AALPLCA9TDP1 | |
| SCHEMBL3342345 | 0.76 | HPGD (0.45) | ALPLCA9 | |
| SCHEMBL31060277 | 0.76 | CCNA2 (0.47) | USP30KMT2AMKNK1MKNK2CCNA2 | |
| SCHEMBL14985498 | 0.75 | MKNK1 (0.56) | USP30DRD4MEN1KMT2AMKNK1 | |
| SCHEMBL4469748 | 0.75 | HCAR2 (0.50) | DRD4MEN1KMT2AMKNK1MKNK2 | |
| SCHEMBL17948808 | 0.73 | CCNA2 (0.60) | USP30DRD4MEN1KMT2AMKNK1 | |
| SCHEMBL3342673 | 0.73 | ALPL (0.39) | MKNK1MKNK2ALPLCA9TDP1 | |
| SCHEMBL4469262 | 0.73 | ALPL (0.51) | DRD4MEN1KMT2ACCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | ROCHE PALO ALTO LLC | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160384-A1 | DIHYDROPYRIDONE AMIDES AS P2X7 MODULATORS | P2RY1, P2RX6, P2RX3 | USP30 4757/4885DRD4 678/4885MEN1 2632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.