Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JMJD6 | Q6NYC1 | 6/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | OGA | O60502 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347544 | 0.77 | OGA (0.40) | OGANPC1RAB9AMEN1KMT2A | |
| SCHEMBL3354058 | 0.76 | PIK3CA (0.50) | JMJD6PIK3CANPC1RAB9AMEN1 | |
| SCHEMBL3561467 | 0.73 | CYP1A2 (0.57) | NPC1RAB9AKMT2AMAPK1KDM4E | |
| SCHEMBL15288593 | 0.72 | SCN5A (0.53) | JMJD6NPC1RAB9AMEN1KMT2A | |
| SCHEMBL508971 | 0.72 | JMJD6 (0.52) | JMJD6PIK3CAKDM4EALDH1A1HPGD | |
| SCHEMBL31132513 | 0.70 | MAP4K4 (0.48) | JMJD6PIK3CAMEN1KMT2AMAPK1 | |
| SCHEMBL5680334 | 0.70 | L3MBTL1 (0.46) | JMJD6PIK3CAMEN1KMT2AKDM4E | |
| SCHEMBL3346432 | 0.70 | GRM5 (0.41) | OGAALDH1A1 | |
| SCHEMBL3347027 | 0.69 | GRM5 (0.50) | — | |
| SCHEMBL3346985 | 0.69 | GRM5 (0.42) | OGAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |