Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 12/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347130 | 0.84 | CA12 (0.38) | ALOX5DYRK1ASCN5ACYP1A2 | |
| SCHEMBL3347309 | 0.84 | GRM5 (0.53) | GRM5TGFBR1 | |
| SCHEMBL3347060 | 0.82 | GRM5 (0.35) | GRM5TGFBR1SCN5A | |
| SCHEMBL3347237 | 0.82 | GRM5 (0.46) | GRM5ALOX5PDE10A | |
| SCHEMBL3346788 | 0.81 | GRM5 (0.32) | GRM5DYRK1ATGFBR1SCN5A | |
| SCHEMBL3346516 | 0.80 | ALOX5 (0.37) | GRM5ALOX5DYRK1ATGFBR1SCN5A | |
| SCHEMBL3345871 | 0.80 | CHRM2 (0.35) | GRM5DYRK1ATGFBR1SCN5A | |
| SCHEMBL3346865 | 0.80 | CHRM2 (0.35) | GRM5DYRK1ASCN5A | |
| SCHEMBL3347007 | 0.80 | GRM5 (0.43) | GRM5CYP1A2 | |
| SCHEMBL3347351 | 0.79 | SCN5A (0.31) | SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |