Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.30 |
| ▸ | GABRP | O00591 | 1/20 | 0.30 |
| ▸ | GABRD | O14764 | 1/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346865 | 0.85 | CHRM2 (0.35) | GRM5CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3345871 | 0.85 | CHRM2 (0.35) | TGFBR1GRM5CHRM2CHRM1DYRK1A | |
| SCHEMBL3347174 | 0.83 | ALOX5 (0.36) | ALOX5GRM5FFAR1 | |
| SCHEMBL3347130 | 0.82 | CA12 (0.38) | ALOX5CHRM2CHRM1DYRK1ASCN5A | |
| SCHEMBL3347020 | 0.80 | CYP2A6 (0.36) | TGFBR1CHRM2CHRM5CHRM1OGA | |
| SCHEMBL3348468 | 0.80 | GRM5 (0.45) | ALOX5TGFBR1GRM5DYRK1ASCN5A | |
| SCHEMBL3347309 | 0.80 | GRM5 (0.53) | TGFBR1GRM5 | |
| SCHEMBL3347005 | 0.79 | ALOX5 (0.40) | ALOX5TGFBR1GRM5FFAR1DYRK1A | |
| SCHEMBL3347007 | 0.78 | GRM5 (0.43) | GRM5 | |
| SCHEMBL3346788 | 0.77 | GRM5 (0.32) | TGFBR1GRM5CHRM2CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |