Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347267 | 0.81 | TGFBR1 (0.45) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3345835 | 0.78 | MAPT (0.40) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3347002 | 0.76 | MEN1 (0.40) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3348254 | 0.75 | EPHB3 (0.42) | MEN1NPC1RAB9AKMT2ACAMKK1 | |
| SCHEMBL711033 | 0.72 | LMNA (0.55) | SMN1; SMN2MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3346812 | 0.71 | PIM1 (0.40) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| Benzene SCHEMBL28197607 | 0.71 | LMNA (0.52) | SMN1; SMN2MEN1NPC1RAB9AKMT2A | |
| SCHEMBL860236 | 0.70 | PARP1 (0.43) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL29220732 | 0.69 | CAMKK1 (0.44) | MAPTSMN1; SMN2MEN1NPC1RAB9A | |
| SCHEMBL3045043 | 0.68 | LMNA (0.48) | SMN1; SMN2MEN1NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |