Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.42 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3347002 | 0.87 | MEN1 (0.40) | EPHB3IRAK4NPC1RAB9ACAMKK1 | |
| SCHEMBL3347267 | 0.75 | TGFBR1 (0.45) | EPHB3IRAK4NPC1RAB9ACAMKK1 | |
| SCHEMBL3345835 | 0.75 | MAPT (0.40) | NPC1RAB9ACAMKK1CAMKK2MEN1 | |
| SCHEMBL3346812 | 0.71 | PIM1 (0.40) | NPC1RAB9ACAMKK1CAMKK2MEN1 | |
| SCHEMBL14897458 | 0.69 | NTRK1 (0.46) | EPHB3IRAK4RAB9ATGFBR1 | |
| SCHEMBL11225958 | 0.68 | RAB9A (0.62) | NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14897663 | 0.68 | ALDH1A1 (0.52) | EPHB3ADORA3TMIGD3TGFBR1 | |
| SCHEMBL3346996 | 0.67 | MEN1 (0.41) | NPC1CYP3A4RAB9ACAMKK1CAMKK2 | |
| SCHEMBL16180212 | 0.66 | IRAK4 (0.60) | IRAK4IDO1TDO2KDR | |
| SCHEMBL16620804 | 0.66 | KDM4E (0.43) | NPC1RAB9ACAMKK1CAMKK2CAMK2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |