Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHB3 | P54753 | 2/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.37 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348254 | 0.87 | EPHB3 (0.42) | MEN1NPC1RAB9AKMT2AEPHB3 | |
| SCHEMBL3048096 | 0.77 | ALDH1A1 (0.55) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL3347267 | 0.77 | TGFBR1 (0.45) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL3351360 | 0.76 | MAPT (0.38) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL3345835 | 0.76 | MAPT (0.40) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL22162325 | 0.65 | IRAK4 (0.50) | IRAK4JAK1TYK2JAK3 | |
| SCHEMBL22097340 | 0.65 | EPHB3 (0.39) | SMN1; SMN2EPHB3RETIRAK4ALDH1A1 | |
| SCHEMBL4786596 | 0.65 | KDM4E (0.56) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL6511540 | 0.64 | HDAC1 (0.46) | MEN1NPC1MAPTRAB9AKMT2A | |
| SCHEMBL16180149 | 0.64 | EPHB3 (0.45) | MEN1KMT2AEPHB3TGFBR1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |