Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.31 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.31 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346218 | 0.86 | DYRK1A (0.42) | DYRK1ASCN5APIK3CDTGFBR1USP30 | |
| SCHEMBL3347243 | 0.86 | DYRK1A (0.44) | DYRK1ASCN5APIK3CDTGFBR1MAPT | |
| SCHEMBL3347294 | 0.85 | DYRK1A (0.42) | DYRK1ASCN5ATGFBR1MAPTKMT2A | |
| SCHEMBL3346482 | 0.84 | DYRK1A (0.45) | DYRK1ASCN5APIK3CDTGFBR1MAPT | |
| SCHEMBL3346918 | 0.83 | DYRK1A (0.41) | DYRK1ASCN5APIK3CDTGFBR1MAPT | |
| SCHEMBL3346989 | 0.83 | DYRK1A (0.39) | DYRK1ASCN5APIK3CDTGFBR1ALDH1A1 | |
| SCHEMBL3353764 | 0.78 | EGLN1 (0.31) | — | |
| SCHEMBL3347657 | 0.74 | CCNE1 (0.33) | — | |
| SCHEMBL2202069 | 0.68 | DYRK1A (0.49) | DYRK1ASCN5APIK3CDTGFBR1KDR | |
| Hydrochloric Acid SCHEMBL5121050 | 0.67 | BRD4 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |