Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNN3 | Q9UGI6 | 8/20 | 0.38 |
| ▸ | GRM5 | P41594 | 6/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND1 | P24385 | 1/20 | 0.33 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | CDK3 | Q00526 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | KCNN1 | Q92952 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346921 | 0.90 | KCNN3 (0.37) | KCNN3GRM5CDK2CCNT1CDK1 | |
| SCHEMBL3346499 | 0.89 | CDK2 (0.35) | KCNN3CDK2CCNT1CDK1CDK4 | |
| SCHEMBL3345910 | 0.89 | GRM5 (0.35) | GRM5CDK2CCNT1CDK1CDK4 | |
| SCHEMBL3348362 | 0.86 | CDK2 (0.39) | GRM5CDK2CCNE1 | |
| SCHEMBL3347209 | 0.84 | KCNN3 (0.36) | KCNN3GRM5CDK2CCNT1CDK1 | |
| SCHEMBL3351298 | 0.83 | GRM5 (0.33) | GRM5 | |
| SCHEMBL3346746 | 0.82 | KCNN1 (0.38) | KCNN3GRM5CDK2CCNT1CDK1 | |
| SCHEMBL3345946 | 0.82 | GRM5 (0.39) | KCNN3GRM5CDK2CCNT1CDK1 | |
| SCHEMBL3351751 | 0.81 | CDK2 (0.38) | KCNN3GRM5CDK2CCNT1CDK1 | |
| SCHEMBL3347648 | 0.81 | GRM5 (0.33) | KCNN3GRM5CDK2CCNT1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | claimed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |