Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 2/20 | 0.51 |
| ▸ | HTR1B | P28222 | 2/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR1F | P30939 | 1/20 | 0.51 |
| ▸ | NOS3 | P29474 | 6/20 | 0.48 |
| ▸ | NOS1 | P29475 | 6/20 | 0.48 |
| ▸ | NOS2 | P35228 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SCD | O00767 | 7/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12253683 | 0.94 | NOS3 (0.55) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL2266494 | 0.88 | PRKCI (0.51) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL30594683 | 0.88 | PRKCI (0.51) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL3358885 | 0.85 | DRD2 (0.67) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL3357163 | 0.84 | OPRM1 (0.43) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL3355691 | 0.84 | DRD2 (0.52) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL12367572 | 0.83 | NOS3 (0.54) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL3355266 | 0.83 | NOS3 (0.45) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL3355563 | 0.82 | OPRM1 (0.47) | HTR1DHTR1BHTR1AHTR1FNOS3 | |
| SCHEMBL6742084 | 0.82 | HTR1A (0.51) | HTR1DHTR1BHTR1AHTR1FNOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| CN-1510034-A | Indazole compound, preparing method thereof and medicine composition containing the same | ɪά��ʵ���� | 2004-07-07 | — | — | CN | disclosed |
| EP-0902027-B1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR (FR) | 2001-07-25 | — | — | EP | disclosed |
| US-6046205-A | FOR TREATMENT OF VENOUS INSUFFICIENCY AND OF ASSOCIATED DISORDERS, AND ALSO IN THE TREATMENT OF MIGRAINE | ADIR ET COMPAGNIE (FR) | 2000-04-04 | — | — | US | disclosed |
| US-6020336-A | Indole and indazole compounds | LES LABORATOIRES SERVIER (FR) | 2000-02-01 | — | — | US | disclosed |
| EP-0902027-A1 | Indole and indazole derivatives, process for their preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1999-03-17 | — | — | EP | disclosed |