Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.47 |
| ▸ | NOS3 | P29474 | 3/20 | 0.42 |
| ▸ | NOS1 | P29475 | 3/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 6/20 | 0.39 |
| ▸ | OGFRL1 | Q5TC84 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12253683 | 0.83 | NOS3 (0.55) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3352865 | 0.82 | HTR1D (0.51) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL13537242 | 0.81 | NOS3 (0.45) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3355691 | 0.79 | DRD2 (0.52) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3357163 | 0.79 | OPRM1 (0.43) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3355266 | 0.78 | NOS3 (0.45) | NOS3NOS1NOS2HTR7DRD2 | |
| SCHEMBL12459068 | 0.78 | KDM4C (0.39) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3351996 | 0.78 | ASH1L (0.43) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3357757 | 0.78 | NPC1 (0.47) | OPRM1OPRD1OPRK1OPRL1NOS3 | |
| SCHEMBL3358885 | 0.77 | DRD2 (0.67) | NOS3NOS1NOS2HTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |
| EP-2141163-A1 | Substituted thiazolidinones, their production and utilisation as medicine | Bayer Schering Pharma AG (DE) | 2010-01-06 | — | — | EP | disclosed |