Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.52 |
| ▸ | PDE2A | O00408 | 10/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3346531 | 0.88 | GPR88 (0.66) | GPR88KCNH2KCNQ3KCNQ2TDP1 | |
| SCHEMBL3353031 | 0.87 | KCNH2 (0.59) | PDE2AKCNH2GPR139KCNQ3KCNQ2 | |
| SCHEMBL3353012 | 0.87 | KCNH2 (0.59) | GPR88KCNH2KCNQ3KCNQ2TDP1 | |
| SCHEMBL3346914 | 0.79 | KCNH2 (0.52) | PDE2AKCNH2GPR139KCNQ3KCNQ2 | |
| SCHEMBL3416539 | 0.79 | GPR88 (0.45) | GPR88KCNH2KCNQ3KCNQ2TDP1 | |
| SCHEMBL3353261 | 0.79 | GPR88 (0.46) | GPR88KCNQ3KCNQ2TDP1 | |
| SCHEMBL3348200 | 0.78 | KCNH2 (0.52) | KCNH2GPR139 | |
| SCHEMBL3353035 | 0.78 | MC4R (0.56) | KCNH2 | |
| SCHEMBL17230469 | 0.74 | GPR88 (0.66) | GPR88KCNQ3KCNQ2 | |
| SCHEMBL3412005 | 0.74 | KCNH2 (0.55) | GPR88KCNH2KCNQ3KCNQ2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010059922-A1 | PYRROLIDINE CARBOXAMIDE COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2010-05-27 | — | — | WO | claimed |