Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | RPS6KA3 | P51812 | 7/20 | 0.34 |
| ▸ | SRC | P12931 | 7/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.34 |
| ▸ | ABL1 | P00519 | 6/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.34 |
| ▸ | PRKDC | P78527 | 6/20 | 0.34 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | HCK | P08631 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | MTOR | P42345 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31304384 | 1.00 | ADORA3 (0.41) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL15072857 | 0.80 | ADORA3 (0.42) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL15077058 | 0.79 | ADORA3 (0.41) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL15970859 | 0.79 | HDAC8 (0.50) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL14819959 | 0.76 | ADORA3 (0.43) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL26259234 | 0.76 | ADORA3 (0.54) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL1980691 | 0.76 | PI4KA (0.43) | KDM4EAURKASRCPIK3CDPIK3CA | |
| SCHEMBL15971027 | 0.75 | IRAK4 (0.46) | — | |
| SCHEMBL16409134 | 0.73 | ADORA3 (0.55) | ADORA3ADORA2AADORA2BADORA1KDM4E | |
| SCHEMBL29730504 | 0.73 | ALDH1A1 (0.44) | ADORA3ADORA2AADORA2BADORA1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461159-B2 | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase | Jannsen Pharmaceutica BV (BE) | 2013-06-11 | — | — | US | claimed |
| WO-2010068453-A1 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA NV (BE) | 2010-06-17 | — | — | WO | claimed |
| US-8877769-B2 | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase | JANSEEN PHARMACEUTICA NV (BG) | 2014-11-04 | — | — | US | disclosed |
| US-20130245022-A1 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | JANSSEN PHARMACEUTICA NV (US) | 2013-09-19 | — | — | US | disclosed |
| US-8461159-B2 | Heteroaryl-substituted urea modulators of fatty acid amide hydrolase | Jannsen Pharmaceutica BV (BE) | 2013-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245022-A1 | HETEROARYL-SUBSTITUTED UREA MODULATORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, GPR119 | ADORA3 766/4885ADORA2A 484/4885ADORA2B 436/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.